Scientific facts about Epitalon

Epitalon and telomeres, the major players in fighting aging!

Below we list a few studies that are showing how long telomeres are crucial to live a long and healthy life.

During scientific studies, it has been shown that the addition of Epitalon tetrapeptide (Ala-Glu-Asp-Gly) in a culture of human lung fibroblasts induced gene expression of telomerase and the length of telomeres was multiplied by 2.4. The activation of gene expression is accompanied by an increased number of cell divisions (42.5%), which is evidence of exceeding the Hayflick limit [1,2].

Epitalon is the only supplement that has ever been proved by scientific studies to lenghten telomeres. Today, if you want to live longer, you have to repare and restart manufacturing telomeres to protect the ends of your genes, to enable your cells to replicate without DNA errors, and beyond the Hayflick limit.

# The body’s clock that control almost all signs of aging is well know from scientists

telomeres-studiy-danish-2009Every year new studies are published that show the common factor between people who are healthier and younger-looking than other people their age: longer telomeres.[3,4,5]
That’s why keeping your telomeres long and healthy is one of the most important things you can do to keep the rest of your body youthful and strong.

 

# Identical Twin Study Shows Longer Telomeres Make You “Younger”

There was a study of identical twins – one of the most interesting and useful kind of studies you can have. Participants were asked to look at photos of 913 pairs of twins, side by side, and choose which one of the twins looked younger.
When they looked at the photos, the twin that looked younger turned out to be the one with the longer telomeres. These twins also had better health than their older-looking siblings.[5]
And that’s not the only thing that studies show us about telomeres. Research also shows us that every part of your body is affected by shortening telomeres. It gets harder for your heart, brain, kidneys, lungs, pancreas and other organs to do their jobs as your telomeres get shorter.

Here’s an example. There’s a type of tissue in your cardiovascular system called endothelium. When this tissue does its job, your heart is strong. When this tissue is damaged by oxidative stress from free radicals, telomere length is also affected.
There are a lot of factors that determine whether your heart will stay in peak condition, but maintaining your telomeres is one more step you can take. Research shows us that healthy individuals have longer telomeres in their endothelium.[6]
It all makes you wonder how shorter telomeres could be holding you back, and how keeping them longer could propel you forward…

 

# Among 100 years old people, the healthier are those with longer telomeres

If you want a prove of how much telomeres matter, check the oldest people’s DNA!
In a study of 38 people who were 100 years or older, the healthiest ones had the longest telomeres. They had stronger heart and lung function, healthy blood sugar, and better brain function than those with shorter telomeres.[7]

[1] Epitalon peptide induces telomerase activity and telomere elongation in human somatic cells. // Bulletin Exp. Biol. Med. (Rus). – 2004. Click here
[2] Peptide promotes overcoming of the division limit in human somatic cell // Bulletin Exp. Biol. Med. (Rus). – 2004. Click here
[3] Shortened telomere length in white blood cells of patients with IDDM. Jeanclos E, et al. Diabetes. 1998; 47(3): 482-486. Click here
[4] Telomere biology in cardiovascular disease: the TERC-/- mouse as a model for heart failure and ageing. Wong LSM, et al, Eur J Heart 2008. Click here
[5] Perceived age as clinically useful biomarker of ageing: cohort study. Christensen, Kaare, et al, BMJ. 2009; 339:b5262. Full text free, click here
[6] Telomere shortening in human coronary artery diseases. Ogami M, et al, Arterios Thromb Vasc Bio. 2004; 24: 546-550. Click here
[7] Association of longer telomeres with better health in centenarians. Terry DF, et al, Journals of Gerontology: Series A. 2008; 63(8): 805-812. Click here

 

# Science has shown that Epitalon is the most powerful factor ever found to stop the aging of the human body and to rejuvenate it.

This is the only product that is scientifically proven in clinical studies in humans and in laboratory studies on cells.
telomeres_chromosome
Since telomerase was discovered, it is known to be responsible for the construction and repair of telomeres, the protective ends of the strands of our DNA, which allow seamless and endless duplication of this DNA during the production of new cells.

Excerpt (from French): [Reference 1]
The Nobel of Medecine was awarded to three Americans, for their work ontelomerase, an enzyme that could be the key to eternal youth.
“The solution to a major problem”
“This year’s Nobel Prize in Physiology or Medicine is awarded to three scientists who found the solution to a major problem in biology: how the chromosomes can be completely copied during cell division and how they are protected against degradation,” according the statement of the Committee.
“The Nobel Laureates have shown that the solution lay in the endings of chromosomes, telomeres, and in an enzyme that forms them, telomerase,” he adds.
“These findings have added a new dimension to our understanding of cell and informed the disease mechanisms and stimulated the development of potential new therapies,” the statement concluded.
End of excerpt.

Telomerase allows healthy cells to reproduce beyond the usual limit, to rejuvenate the body indefinitely without surgery, chemicals or hazardous materials.
Epitalon is the best known so far to reactivate the production of telomerase in our cells, and so to lengthen our telomeres during cell reproduction.
nouvelle-vie-logo-epitalon-big

A regular intake of Epitalon can provide telomerase throughout the cell duplication, and gradually lengthen the telomeres of all our cells and rejuvenate the whole body!
Like all our cells do not reproduce at same time, some cycles are shorter or longer depending on the organs involved and also the conditions of life and the nutrition of each person, it is important to take Epitalon on a regular basis and for as long as possible.

Epitalon has been tested successfully for many years (1992-2007) by the scientists from the Institute of Gerontology of St. Petersburg.[2]
That shows how much it is safe, as renowned scientists have taken it themselves for years.

The results show an increase in the duration of healthy life by more than 7 years, taking Epitalon over a period of 12 years and only 20 days per year by the already aged scientists.
We can conclude that taking Epitalon permanently will allow us to live healthy and almost endlessly!

That is why Epitalon is the only telomerase activator which we can be sure of the effectiveness and benefits over the long term.
All other products called “telomerase activators” have no proven effects by scientific literature and even less by clinical studies on humans or even cells.

The temptation is great to buy a product cheaper than Epitalon believing it has the same effect, but unfortunately this is not the case, as only Epitalon is a proven telomerase activator.

Here are some of the many published scientific studies on Epitalon among the long official list [3]:

– In May 2004: A peptide (Epitalon) overcomes the limit of cell division in human somatic cells. [4]
– In June 2003: Epithalon peptide (Epitalon) induces telomerase activity and telomere elongation in human somatic cells. [5]
– In August 2002: Epitalon slows aging and suppresses the development of breast cancer in HER-2/neu mice. [6]
– In November 2000: Effects of Epithalone (Epitalon) on age-related changes in lipid peroxidation in the fly Drosophila melanogaster. [7]

I will contact you soon for further scientific studies on the effects of Epitalon against cancer, for the repair of the pineal gland and repair of the retina of the eye, etc. …

Telomere length is associated with all chronic diseases associated with ageing, which means that when the body breaks down, the telomeres shorten and vice versa. And when the telomeres reach their lower limit, they become too short for the cell to reproduce.
Cells stopping to duplicate and thus prevent the body to renew itself, and organs are missing new cells to repair themselves, and begin gradually to function less and less, and finally stop working completely.

It is the whole body that needs to be repaired regularly and Epitalon allows cells to continue to reproduce division after division, lengthening telomeres, exceeding the limit of this biological clock that condemns us to die so quickly, when life is so good.

This telomere repair also prevents the proliferation of cancer cells, which are nothing more than cells that were poorly duplicated, because telomeres had become too short (I will provide references to scientific studies which demonstrate that, in a next post)

I hope that this scientific approach suits you, although unfortunately all these publications are still in technical terms.

The exceptional effects of Epitalon are not based on false evidence or on placebo effects, as some would have us believe, but on scientific and clinical studies published internationally for many years.

Moreover, the Epitalon sold by Biotrends is the same as that used in various scientific studies, and that is purchased in large quantities by universities worldwide. This is the best quality guarantie you could ask for!
Indeed there is a great growing international interest in Epitalon and its exceptional effects, and new studies are being conducted, but we will have the results in the coming years, some taking place over long periods.

People who take Epitalon regularly will confirm you the effects they feel, and the good health that goes with it, and that gets better over the years, all the organs of the body being gradually repaired and cells continuously rejuvenated.

Epitalon is the best investment for a GOOD HEALTH!

The references cited above:

[1] Le Nobel de Médecine à un trio américain pour la télomérase. Article du Nouvel Observateur.Online here, in French
[2] Regulating Ageing with peptides. Insitute of Gerontologie of St Petersburg. Online here
[3] List of Publications by Professeur Khavinson. Online here
[4] Bulletin of Experimental Biology and Medicine. May 2004, Volume 137, Issue 5, pp 503-506. Buy it here
[5] Bulletin of Experimental Biology and Medicine. June 2003, Volume 135, Issue 6, pp 590-592. Buy it here
[6] Free here
[7] Free here

 

# The anti-aging effects Epitalon are scientifically proven by numerous scientific studies for many years.

More than 100 studies have been published in English on Epitalon [1]. Even more if we add other languages, including Russian, where Epitalon is studied since the 1970s [2].
glandes-endocrines-wikipedia
In the early 1970s, the Institute of Gerontology of St Petersburg, Russia, including Professor Khavinson, began to study the immunosuppressive mechanism of the body, both experimentally and clinically. They found that with age there was a deterioration of the functioning of the central organs of the immune system, the thymus(a), and the neuroendocrine system, the pineal gland (b)[3].
To restore the function of the pineal gland they have isolated and refined a small peptide that mimics its actions, which the synthesis is Epitalon, which does not have to use animals as a source [5,6].

Isolated from the epiphysis or pineal gland, this peptide (the Epithalamine then replaced by Epitalon) was studied in different biological models. This peptide has contributed to a significant increase in the duration of animal life in many experiments [5,6,7,8,9,10].
This significant increase in the life of animals was obviously caused by an anti-tumor activity of this peptide isolated from the pineal gland [7,8,10,11,12].

A particularly significant effect was the restoration of function of the reproductive system in older female rats subjected to treatment with the peptide from pineal gland. Equivalent to menopause in women animal, the estrus stage, at 95% fell down to 52% after administration of the preparation. A special experiment was made with female rats that did not become pregnant after mating, but after administration of the peptide from pineal gland and several other couplings, 4 of the 16 female rats fell pregnant, giving birth to 5-9 babies each [6].

Such results of studies have demonstrated the potential use of this peptide as a protector against aging, gerontology protective [13,14,15].
The antimutagenic and reliable remedial activities of the pineal peptide was confirmed by a reduction in the number of errors of chromosome replication of bone marrow cells and corneal epithelium in animals suffering from accelerated aging [17].

Concerning the regulation of gene activity, it was established that the administration of Ala-Glu-Asp-Gly peptide (Epitalon) in transgenic mice resulted in a reduction by 2 to 3.6 times of the expression HER2/neu (human breast cancer) gene. This decrease is accompanied by a consistent reduction in the diameter of the tumor [16].

It has been shown that the addition of Epitalon tetrapeptide (Ala-Glu-Asp-Gly) in a culture of human lung fibroblasts induced gene expression of telomerase and the length of telomeres was multiplied by 2.4. The activation of gene expression is accompanied by an increased number of cell divisions (42.5%), which is evidence of exceeding the Hayflick limit (c) [18,19].

The first results of scientific studies on the Epitalon / Epithalamine were published in 1979. But the clinical study that has completely revolutionized the science of human ageing was published in 2002 by the Institute of Gerontology and Professor Khavinson, because it showed a very significant reduction in the mortality of participants, up to 4 times less for those who took Epitalon! [4]
It lasted seven years and concerned 266 scientists over the age of 60, who took the peptide during the first 3 years, except for a specific group that took it for 6 years (see below), showing that Epitalon has an huge impact on the long term too.

The results proved that we can regulate and standardize the basic functions of the body through such a bio regulator. Significant improvements were recorded on the cardiovascular, endocrine, immune and nervous systems, and homeostasis and metabolism of the organism as a whole.

For example they recorded 2 to 2.5 times fewer respiratory illnesses, fewer heart problems, less hypertension, less arteriosclerosis and less osteoporosis, which spawned a far less mortality during the period of this study , compared to the group that did not take Epitalon.
There were almost two times fewer deaths in the group taking the Epitalon and 2.5 times less in the group taking the Epitalon and at the same time Vilon (thymus peptides).

Another group took Epitalon and Vilon every year for 6 years, and mortality was four times less elevated compared to the untreated group!
This proves without doubt that the results are better with a regular intake instead of a single course. This makes sense when you know that Epitalon generates longer telomeres and allows the cells to reproduce much longer.
Each course or dose of Epitalon gives you the ability to regenerate cells to repair the entire body.

DePinho-mices-rejuvenated
# Professor DePinho found the same results in mice when he reactivated the production of telomerase in their cells.

“These mice were equivalent to age 80 years in human, and were about to die,” said Ronald DePinho, co-author of the study and researcher at the Dana-Farber Cancer Institute in Boston. After the experiment, “they were back to the physiological equivalent of young adults.”

The experiment focused on telomerase, an enzyme that makes the units of DNA that seal the ends of chromosomes, called telomeres.

As people age, their low levels of telomerase are associated with telomere erosion. Dr. DePinho and his colleagues wanted to see whether reactivating telomerase in mice could slow down, reverse telomere shortening.

A month later, the treated mice showed surprising signs of rejuvenation. Overall, their telomeres were elongated and had increased levels of telomerase. This has awakened the dormant brain stem cells, which have begun to produce new neurons. Spleen, testes and brain grew in size [20].
Read the entire page

The references cited above:

[1] More than 100 studies Click here
[2] Experimental research on ageing in Russia. Click here
[3] Peptide regulation of ageing. Click here
[4] Geroprotective effect of thymalin and epithalamin. Click here
[5] Study of the anti-tumor effect of polypeptide pineal extract // Oncology. – 1979. Click here
[6] Increase in lifespan of rats following polypeptide pineal extract treatment // Exp. Pathol. – 1979. Click here
[7] Effect of low-molecular-weight factors of thymus, pineal gland and anterior hypothalamus on immunity, tumor incidence and lifespan of C3H/Sn mice // Mech.Ageing Dev. – 1982. Click here
[8] Effect of low-molecular-weight factors of thymus and pineal gland on lifespan and spontaneous tumour development in female mice of different age // Mech. Ageing Dev. – 1989. Click here
[9] The pineal peptides: interaction with indoles and the role in aging and cancer // Neuro-endocrinology: New Frontiers.Click here
[10] Effect of pineal peptide preparation (epithalamin) on lifespan and pineal and serum melatonin level in old rats // Ann. N.Y. Acad. Sci. – 1992. Click here
[11] Bioactive peptides from bovine pineal gland and bone marrow extracts. In: «Chemistry of Peptides and Proteins» DWI Report: Aachen. – 1993.
[12] Twenty years of study on effect of pineal peptide preparation: epithalamin in experimental gerontology and oncology // Ann. N.Y. Acad. Sci. – 1994. Click here
[13] Approach to the prophylaxis and treatment of age-related pathology // Romanian J. of Gerontology and Geriatrics. – 1998.
[14] Claude Bernard was right: hormones may be produced by “non-endocrine” cells // Neuroendocrinology Lett. – 2000.Click here
[15] US Patent N 6,727,227 B1 «Tetrapeptide revealing geroprotective effect, pharmacological substance on its basis, and the method of its application»; 27.04.2004.
[16] Inhibitory effect of the peptide epitalon on the development of spontaneous mammary tumors in Her-2/NEU transgenic mice // Int. J. Cancer. – 2002. V. 101. – P. 7-10. Free here : Click here
[17] Spontaneous mutagenesis, carcinogenesis and aging in SAM mice: effect of melatonin, epitalon and neuronal // Proceedings of the 19th SAM meeting. – Ed. T.Takeda. Kyoto. – 2004.
[18] Epitalon peptide induces telomerase activity and telomere elongation in human somatic cells. // Bulletin Exp. Biol. Med. (Rus). – 2004. Click here
[19] Peptide promotes overcoming of the division limit in human somatic cell // Bulletin Exp. Biol. Med. (Rus). – 2004. Click here
[20] Telomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice. Nature. 2011. Click here

(a)- Wiki on thymus Click here
(b)- Wiki on pineal gland Click here
(c)- Wiki on Hayflick limit Click here

 

# Telomeres shortening during childhood :

telomeres_chromosome-article-la-rechercheExcerpt from a recent article in the french scientific magazine “La Recherche” (The Research) of June 2014 :

Growing up in a poor and unstable environment alters the genome.
We know that stress contributes to accelerate a natural process in adults : the shortening of telomeres (the protective ends of chromosomes) with age. But this is the first time a study is conducted in children (40 boys aged 9 years).
Researchers at the University of Michigan found that the telomeres of those living in difficult conditions were shorter by 19% compared to children from privileged backgrounds.
Conversely, children whose mothers had higher education have 32 % longer telomeres, and those who grow up in a stable family had telomere 40% longer than children living in a deconstructed family unit.
However, short telomeres, over time, alter the chromosomes and increase the risk of contracting age related diseases. (End of quote)

 

# Epitalon prevent degradation of the immune system!

Epitalon acts on many levels in our organism, as evidenced by the many scientific studies on Epithalon (already more than 100 to date), and the numerous testimonials of its users.

lymphocyte-systeme-immunitaire-epitalonHere is a scientific study that shows that Epitalon (the peptide Ala-Glu-Asp-Gly) also has the ability to activate the proliferation of lymphocytes, which is an essential element in the fight against aging while staying healthy.

Excerpt : “The decrease of lymphocyte interferon gamma expression during aging is one of the main mechanisms leading to the immunodeficiency state in the elderly. Cell penetrating geroprotective peptide Ala-Glu-Asp-Gly has the capability to activate the proliferation of lymphocytes in thymus during its aging.
The nucleotide sequence which is complementary contacted with peptide Ala-Glu-Asp-Gly was found in promoter region of interferon gamma gene.
Thus, the immune protection of this peptide can be explained by its activation of the interferon gamma production in T-cells.”[1]

A young and healthy immune system can effectively counter the attacks against our organism. These attacks can take many forms :

– The physico-chemical attacks; mechanical (friction, impact, fall, etc.), climate (altitude, sudden change in temperature, radiation, drought, dust, etc.), and attacks by chemicals (acids, bases, etc.) or other elements (aluminum, etc.)
Assaults by other living beings; the attackers in this case can be: viruses, bacteria, fungi, yeasts, helminths, arthropods and prions.

The immune system is a key element in the life of our cells, for it is he, through the T lymphocytes (“T” because these cells mature in the thymus after birth in the bone marrow), which get rid of invading pathogens. [2]

Older people suffer more often and more severely from infections than younger people.

We have long known that seniors are more frequently and severely affected by infectious diseases than young ones.
Several factors weigh in favor of an infection in the elderly. At an advanced age, the skin and mucous membranes are more damaged, germs can easily enter the body. Moreover, chronic diseases typically present with age, such as arteriosclerosis (calcification of the arteries) and diabetes inhibit wound healing and the immune system.
We know that the immune system of a ‘young’ can react faster and more effectively against a microbe than a senior one.

During his life, a human being is faced with many microbes, fought fortunately in most cases victoriously by the immune system . Most of the time, this victorious battle takes place without us being aware of it. Sometimes we suffer from fever and other symptoms, consequences of this struggle. There are also germs (especially viruses) that are controlled and mitigated by the body, but that it can not make them disappear completely.

There is probably a price to pay : we believe that these chronic infections cause the immune system to use a lot of its energy, and with time, it is no longer able to react sufficiently quickly and effectively against the new infections. It’s the same with vaccination in elderly people . To create a sufficient protection, it is necessary to have a fully functional immune system. [3]


nouvelle-vie-logo-epitalon-bigEpitalon has been tested successfully for many years (1992-2007) by the scientists from the Institute of Gerontology of St. Petersburg.
[ 4]
That is to say how much it is without any danger, as renowned scientists have themselves taken it formany years.

The results show an increase in the duration of healthy life by more than 7 years, taken over a period of only 12 years and only 20 days per year by these already aged scientists.
That is why it is the only telomerase activator which you can be sure of the effectiveness and benefits over the long term .

We can conclude that taking Epitalon permanently will allow us to live healthy and almost endlessly !

All other products called “telomerase activators” have no proven effects by scientific literature and even less by clinical studies on humans or even cells.
The temptation is great to buy a product cheaper than Epitalon believing it has the same effect, but unfortunately this is not the case, as only Epitalon is a proven telomerase activator.

[1] PMID: 23289226 – Peptide Ala-Glu-Asp-Gly and interferon gamma: their role in immune response during aging. Online here Online here
[2] The immune system on Wikipedia. Online here Online here
[3] The aging of the human immune system. Online here in French Online here
[4] Regulation of aging with peptides. Institute of Gerontology of St. Petersburg. Online here