July 10, 2016

What are the factors that prolong life?

Humans are apparently the only beings on Earth to take their destiny in hand, especially when it comes to enjoying life, to explore its limits, to stay healthy or live as well and as long as possible.

We put all our faculties and invest our time and money to improve and extend our lives. To summarize, we love life and we intend to preserve it at all costs!

Now hundreds of thousands of scientists around the world are working to find a solution to stop the aging of ourorgans and our bodies as a whole. We live in a wonderful time when progress are constantly arriving.

In this Free Info newsletter I try to share what is used today, but also to make you discover what science is at today, and what the near future reserves us …

The current strategies (source Wikipedia)

Physical activity:

Portrait of smiling people doing power fitness exercise at yoga class in fitness studio

Sport is one of the main topics of study when it comes to good health but also longevity. Everyone was able to experience the benefits of sport on the body, improved mood, ease ensuing to move every day, and improved sleep obtainable with few sessions per week.

But the big question is whether sport can improve health and to what extent, and then find if it can act to increase our longevity …

It seems that sport at low to medium intensity is indeed beneficial to health, as might be expected, but also beneficial to our longevity.

Some scientific extracts on the subject:

-> The influence of physical activity on telomere length …

Extracts from a synthesis of scientific studies on this issue in April 2016

Based upon a comprehensive analysis of current literature and by combining a molecular biology and a sports science perspective, this review examines (1) if a correlation between physical activity load and telomere length (TL) exists,

research on skeletal muscle TL so far is quite limited but suggests that physical exercise with prolonged eccentric muscle contractions rather acts to shorten telomeres, while sports with little eccentric contractions might rather act to lengthen telomeres.

Various studies indicate an increase in telomerase activation through exercise.

-> Exercise and Aging: Can you walk against time?

Excerpts from a Harvard Medical School Article

Some of the changes of aging start as early as the third decade of life. After age 25–30, for example, the average man’s maximum attainable heart rate declines by about one beat per minute, per year, and his heart’s peak capacity to pump blood drifts down by 5%–10% per decade. That’s why a healthy 25-year-old heart can pump 2½ quarts of oxygen a minute, but a 65-year-old heart can’t get above 1½ quarts, and an 80-year-old heart can pump only about a quart, even if it’s disease-free. In everyday terms, this diminished aerobic capacity can produce fatigue and breathlessness with modest daily activities.

Endurance exercise is also the best way to protect the body’s metabolism from the effects of age. It reduces body fat, sensitizes the body’s tissues to insulin, and lowers blood sugar levels. Exercise boosts the HDL (“good”) cholesterol and lowers levels of LDL (“bad”) cholesterol and triglycerides. And the same types of activity will fight some of the neurological and psychologic-al changes of aging.

Endurance exercise boosts mood and improves sleep, countering anxiety and depression. In addition, it improves reflex time and helps stave off age-related memory loss. All in all, many of the changes that physiologists attribute to aging are actually caused by disuse. Using your body will keep it young.

No man can stop the clock, but most can slow its tick and enjoy life as they age with grace and vigor. Jonathan Swift was right when he said, “Every man desires to live long, but no man would be old.” Regular exercise, along with a good diet, good medical care, good genes, and a bit of luck, can make it happen.

Food:

green and red healthy foodNumerous studies have scrutinized the eating habits of millions of people in many countries, in ideological or religious groups, and a ranking of diets and their effects on health and longevity has been done.

It is obvious that what we provide to our bodies is essential since it is the elements that will be used to build, repair and maintain it in good working condition.

I will return later on various important points that have been discovered on the links between food and health. Of course this is the most natural method of prevention and most accessible, but it is nevertheless very neglected in societies where local, social, cultural or ancestral traditions often takes precedence over reason. . .

But aside from the extreme calorie restriction, diet itself has no ability to extend our lives beyond what our genetic heritage allows us to reach.

A healthy diet is able to optimize health and longevity, but in any case, unfortunately, it does give us a significantly long life extension!

Telomeres and their importance:

telomere-telomerase-wikipediaSlowing down the erosion of our telomeres by living a healthy lifestyle seems more and more plausible, as  of scientific publications are studying this possibility.
The problem is that it bring a slower telomere loss but not an extension of their length.
To date the best results show a very moderate slowdown of telomere loss after 5 years of healthy life, which is really little.

-> From a recent study published in the prestigious scientific journal The Lancet:

Context
Telomere shortening in human beings is a prognostic marker of aging, disease and premature morbidity.
We previously found an association between 3 months of comprehensive lifestyle changes and increased telomerase activity in human immune-system cells. We followed up participants to investigate long-term effects.
This time we followed the participants to study the long-term effects.

Results interpretation
Our comprehensive lifestyle intervention was associated with increases in relative telomere length after 5 years of follow-up, compared with controls, in this small pilot study. Larger randomised controlled trials are warranted to confirm this finding.

– Available by clicking this link Effect of comprehensive lifestyle changes on telomerase activity and telomere length in men with biopsy-proven low-risk prostate cancer: 5-year follow-up of a descriptive pilot study The Lancet Oncology, Volume 14, Issue 11, Pages 1112 – 1120, October 2013.

-> Changes in lifestyle that protects the telomeres are the same for all. It is :

Food: significant increase in the consumption of vegetable and fruit reduction with animals and sugary foods or refined products
Physical exercise: regular physical activity of moderate intensity. Of the order of 3 times 1 to 2 hours per week
Stress: reducing sources of stress and practical techniques to manage stress. Relaxation therapy, meditation, massage, relaxation …
Sociability: maintain good relationship with his regular entourage

Of course we have to add tobacco, air pollution and alcohol that accelerate aging by shortening telomeres.

To conclude we can say that if you want to live much longer and in good health, good habits and good attitudes are not enough, unfortunately!
It is essential to recharge your cells, rejuvenate lengthening your telomeres.

-> Long Telomeres are the key to living a long and healthy but also for look younger!

Remember this Danish study which we mentioned in a previous newsletter:

telomeres-studiy-danish-2009

In this study of identical twins – one of the most interesting and useful types of studies you may have. Participants were asked to look at photos of 913 twin pairs, side by side, and choose one of the twins who look younger.
When they looked at the photos, the twins who look younger were shown to be those with the longest telomeres. The study also shows that these twins also had better health than their older siblings. [5]
And that’s not the only thing that studies show us on telomeres. Research also shows that every part of your body is affected by telomere shortening. It becomes more difficult to do their work for the heart, brain, kidneys, lungs, pancreas and other organs, when your telomeres shorten.

– Available by clicking this link Perceived age have Clinically Useful biomarker of aging: cohort study. Christensen, Kaare, et al, BMJ. 2009; 339: b5262.

 

Of course, the extension of our telomeres is more important than spectacular visual effects that happen to many, and that’s why I’m more interested in the long term.

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Good health and long life to you!

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