How important are our telomeres for our cells longevity?
First of all thank you for your registration, and thank you for your interest in your own well-being and longevity.
Another very good reason to keep our telomeres long is their influence on the mitochondrial part of our cells, the power plant in our cells. Science as demonstrated that too short telomeres induce the death of the cell, but also compromises the mitochondria previous to that.
Telomeres dysfunction, due to their progressive shortening, disturbs mitochondria functions and reduces energy production, increases free-radical production, and utlimately starts the cell’s self-destruction.
Keeping long and healthy telomeres is the most important step anyone can take to stop and hope to reverse aging, as without long telomeres cells can’t live nor duplicate, nor even produce energy to supply to our body!
# Telomere dysfunction induces metabolic and mitochondrial compromise
Article published in Nature, 17 February 2011, with 45 scientific references cited.
Telomere dysfunction activates p53-mediated cellular growth arrest, senescence and apoptosis to drive progressive atrophy and functional decline in high-turnover tissues.
Telomere dysfunction is associated with impaired mitochondrial biogenesis and function, decreased gluconeogenesis, cardiomyopathy, and increased reactive oxygen species.
We demonstrate that telomere dysfunction activates p53 which in turn binds and represses PGC-1alpha and PGC-1beta promoters, thereby forging a direct link between telomere and mitochondrial biology. We propose that this telomere–p53–PGC axis contributes to organ and metabolic failure and to diminishing organismal fitness in the setting of telomere dysfunction.
The mitochindria is the power plant of the cell and is very important to stay young and healthy, full of energy!
# A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: a dawn for evolutionary medicine.
Published in 2005. PMID: 16285865 – free access here
Life is the interplay between structure and energy, yet the role of energy deficiency in human disease has been poorly explored by modern medicine. Since the mitochondria use oxidative phosphorylation (OXPHOS) to convert dietary calories into usable energy, generating reactive oxygen species (ROS) as a toxic by-product, I hypothesize that mitochondrial dysfunction plays a central role in a wide range of age-related disorders and various forms of cancer. Because mitochondrial DNA (mtDNA) is present in thousands of copies per cell and encodes essential genes for energy production, I propose that the delayed-onset and progressive course of the age-related diseases results from the accumulation of somatic mutations in the mtDNAs of post-mitotic tissues. The tissue-specific manifestations of these diseases may result from the varying energetic roles and needs of the different tissues.
The variation in the individual and regional predisposition to degenerative diseases and cancer may result from the interaction of modern dietary caloric intake and ancient mitochondrial genetic polymorphisms. Therefore the mitochondria provide a direct link between our environment and our genes and the mtDNA variants that permitted our forbears to energetically adapt to their ancestral homes are influencing our health today.
# Molecular mechanisms of ageing and related diseases.
Published in 2014. PMID: 24798238 – PubMed Copyright 2014 Wiley Publishing Asia Pty Ltd.
Human and other multicellular life species age, and ageing processes become dominant during the late phase of life. Recent studies challenge this dogma, suggesting that ageing does not occur in some animal species. In mammals, cell replicative senescence occurs as early as before birth (i.e. in embryos) under physiological conditions. How the molecular machinery operates and why ageing cells dominate under some circumstances are intriguing questions. Recent studies show that cell ageing involves extensive cellular remodelling, including telomere attrition, heterochromatin formation, endoplasmic reticulum stress, mitochondrial disorders and lysosome processing organelles and chromatins. This article provides an update on the molecular mechanisms underlying the ageing of various cell types, the newly described developmental and programmed replicative senescence and the critical roles of cellular organelles and effectors in Parkinson’s disease, diabetes, hypertension and dyskeratosis congenita.
Our bodies were developed to live a few decades, at most may be 120 years, so we will have to make efforts to enable us to overcome these limits of today, and also to live these many additional years in good health and joy of having a body that feels and is YOUNG!
We can hope that the science of genetics will allow us, in a few decades from now, to live indefinitely by changing our DNA code, copying certain “immortal” animals, but for now we must find a solution to wait until this GENETIC ERA as arrived!
Lengthening the telomeres in our cells is now the greatest discovery ever made, because it prolongs the life of each cell allowing it to reproduce indefinitely and without duplication errors.
We can limit the premature destruction of our telomeres but we can not extend them at will. Or rather we could not, because since the discovery of this limit due to our telomeres, many researchers have invested their time to find a solution.
They made the assumption that there must be a way to stimulate the production of long telomeres in cells, to overcome this deadly biological limit.
# Thousands of products and substances have been tested around the world and in recent decades, and one product has met these conditions over multiple laboratory and human studies in real life conditions.
It is Epitalon, the only substance that is actually scientifically proven as lengthening the telomeres of human cells.
Many products are sold as telomerase activators, but only one really works and has been proven in multiple independent studies, and this is Epitalon.
There is no other product for which there is scientific evidence of its positive activity on telomeres. Ask the sellers of products such as TA-65 or Astragaloside to provide you even a single published scientific evidence, and you will find that they do not have any.
They sell you wind of hope, but nothing works. By cons you can read for yourself the dozens of scientific studies published internationally on Epitalon.
Base your purchase on the science that proves the effect of the product and chose a qualified manufacturer that offers the best quality possible, and so you make a good purchase.
The choice is simple for those who want to extend their life and enable their cells to replicate continuously without fault, take Epitalon!
In addition, Epitalon not only lengthen our telomeres, it also regulates many functions of our body, such as hormonal and immune functions. Many people feel very fast improvements in many areas.
Many studies also confirm the incredible effects of Epitalon on various health problems. We will make a more detailed list soon, stay tuned.
So spread the word, ” Aging is not a fatality , it can be reversed ! “
Epitalon is the best existing investment for GOOD HEALTH !